The Most Effective Fertility Supplements In 2025: A Comprehensive Review

When my husband and I decided to start trying for a baby at 37, I quickly discovered that fertility isn’t something you can take for granted. After six months of negative pregnancy tests and mounting anxiety, I did what most women in my position do—I turned to research, seeking answers and solutions.

Why This Research Matters

As a nutritional scientist specialising in reproductive health, I embarked on a deeply personal investigation into fertility supplements. This wasn’t just professional curiosity; it was a quest to understand how nutritional support could optimise our chances of conception.

What followed was an 18-month journey through scientific literature, product testing, and consultations with fertility specialists. The result is this comprehensive review of fertility supplements that I hope will help others navigate this often overwhelming landscape.

The Science Behind Fertility Nutrition

The connection between nutrition and fertility is well-established in research. Studies consistently show that specific nutrients play critical roles in:

• Hormone production and balance: Essential for regular ovulation in women and sperm production in men
• Egg and sperm quality: Directly impacting fertilisation potential
• Implantation support: Creating optimal conditions for a fertilised egg
• Reducing oxidative stress: Protecting reproductive cells from damage

What surprised me most during my research was the significant gap between what science tells us about fertility nutrition and what most supplements actually deliver. While the supplement industry has exploded with fertility products, the quality, formulation, and efficacy vary dramatically.

What To Look For In Fertility Supplements

After analysing dozens of fertility supplements and speaking with reproductive endocrinologists, I’ve identified key factors that separate truly effective fertility supplements from marketing hype:

1. Bioavailable Nutrient Forms

Not all nutrient forms are created equal. Your body can only use what it can absorb. Look for supplements that contain activated forms of nutrients that are ready for your body to utilise immediately.

For example, methylated B vitamins (like methylfolate instead of synthetic folic acid) are crucial for those with MTHFR gene variations—which affect up to 40% of the population and impact fertility outcomes.

2. Comprehensive Hormone Support

Effective fertility supplements should address multiple aspects of reproductive health, including:

• Folate: Critical for preventing neural tube defects and supporting early development
• Zinc: Essential for egg development, ovulation, and hormone balance
• Vitamin B6: Helps regulate hormonal activity
• Selenium: Supports thyroid function (crucial for fertility)
• Iodine: Vital for thyroid health and hormone production

3. Research-Backed Ingredients

The most effective supplements include ingredients with scientific evidence supporting their fertility benefits. Be wary of products that rely on trendy ingredients without substantiating research.

4. Clean, Transparent Formulations

Your fertility journey is delicate enough without introducing potentially harmful additives into your system. Avoid supplements containing:

• Artificial colours and flavours
• Unnecessary fillers
• Synthetic binders
• Heavy metals and contaminants

Common Red Flags In Fertility Supplements

Through my research, I uncovered several concerning trends in the fertility supplement market:

Synthetic Vs. Natural Nutrients

Many supplements use synthetic versions of nutrients that the body struggles to process effectively. Synthetic folic acid, for instance, can remain unmetabolised in the bloodstream of many women, potentially causing more harm than good for those with certain genetic variations.

“Proprietary Blends” Without Transparency

Some manufacturers hide behind “proprietary blends” without disclosing actual dosages of ingredients. This makes it impossible to know if you’re receiving therapeutic amounts of key nutrients.

Incomplete Formulations

Many supplements focus on only one aspect of fertility (such as egg quality) while neglecting other crucial elements like hormone balance or implantation support.

Manufacturing Quality Concerns

Fertility supplements produced in facilities without proper certifications may contain contaminants or inaccurate dosages—risks no one should take when trying to conceive.

Our Testing Methodology

To ensure the most objective evaluation possible, I developed a rigorous testing methodology:

1. Ingredient Analysis: Evaluation of active ingredients, forms, and dosages against current fertility research
2. Quality Assessment: Manufacturing standards, third-party testing, and contamination risk
3. Bioavailability Testing: How effectively nutrients are absorbed and utilised
4. Value Assessment: Cost-effectiveness of formulations
5. User Experience: Real-world feedback from women at various stages of their fertility journeys

Each product received a rating out of 10 based on these criteria, creating a comprehensive picture of which supplements truly deliver results.

5 Best In Test Fertility Supplements of 2025

After exhaustive research and testing, these are the top fertility supplements currently available:

1. Food-Grown® Fertility Support for Women

Overall Rating: 9.7/10

What immediately sets Food-Grown® Fertility Support apart is its innovative approach to nutrient delivery. Rather than using isolated synthetic vitamins, this supplement bonds essential nutrients with food components, creating a form the body recognises and absorbs efficiently.

The formulation is truly comprehensive, addressing every aspect of fertility I identified in my research. It contains optimal doses of zinc, selenium, and iodine—critical minerals often overlooked in other supplements but essential for thyroid function and hormone balance.

The inclusion of Cordyceps Sinensis (a medicinal mushroom) provides additional support for reproductive health that I didn’t find in other supplements. Research shows this adaptogen helps regulate menstrual cycles and hormone production—a thoughtful addition backed by traditional use and emerging science.

I particularly appreciate the attention to detail in including vitamin B6, which contributes to the regulation of hormonal activity and has been shown to support luteal phase health. The methylated B vitamins ensure that women with MTHFR gene variations can properly utilise these nutrients.

During my testing period, I noticed significant improvements in my cycle regularity and ovulation indicators. My basal body temperature charts showed clearer patterns, and fertility tracking became more predictable—effects that weren’t as pronounced with other supplements I tested.

Pros:

• Exceptional bioavailability through food-grown methodology
• Comprehensive formulation addressing all aspects of fertility
• Contains adaptogens for stress reduction and hormone balance
• Methylated B vitamins for optimal utilisation
• Manufactured in the UK under stringent quality controls
• 60-day money-back guarantee
• Subscribe and save option available

Cons:

• Premium pricing (though justified by quality and results)
• Sometimes out of stock due to high demand
• Requires consistent daily use for optimal results

Wild Nutrition offer a 50% discount for your first 3 months subscription, which is a great way to see if their supplements work for you.

Check Availability

Editor’s note: I’ve seen this go out of stock before, so do check availability

2. CONCEIVE PLUS Women’s Fertility Support

Overall Rating: 8.5/10

Fertility Bloom offers a solid formulation with good coverage of essential fertility nutrients. Their Total Fertility supplement provides standard forms of key vitamins and minerals, though not all are in their most bioavailable forms.

The inclusion of CoQ10 for egg quality support is commendable, though the dosage (50mg) falls short of the 100-300mg range shown in research to significantly impact egg quality.

While this supplement contains most of the nutrients needed for fertility support, it uses synthetic folic acid rather than methylfolate, making it less ideal for women with MTHFR variations.

Pros:

• Good overall nutrient profile
• Includes CoQ10 for egg quality
• Reasonably priced

Cons:

• Uses some synthetic nutrient forms
• Lower doses of certain key ingredients
• Limited adaptogenic support

3. Vitabiotics Pregnacare

Overall Rating: 8.2/10

Vitabiotics’s offering provides decent fertility support with a focus on antioxidant protection. The supplement contains good levels of vitamins C and E, which help protect egg and sperm cells from oxidative damage.

However, the formulation lacks sufficient mineral support, particularly for thyroid function, with suboptimal amounts of selenium and iodine. Given the importance of thyroid health in fertility, this is a notable limitation.

The manufacturing standards are good, with third-party testing for contaminants, but the nutrient forms used are primarily synthetic rather than naturally derived.

Pros:

• Strong antioxidant profile
• Good manufacturing standards
• Transparent ingredient listing

Cons:

• Insufficient thyroid support
• Uses synthetic nutrient forms
• No adaptogenic ingredients

4. FertilAid Multivitamin

Overall Rating: 7.8/10

FertilAid provides a basic fertility supplement at a more accessible price point. The formulation covers fundamental nutrients needed for conception but lacks the comprehensive approach of higher-rated options.

The supplement uses standard forms of vitamins and minerals without the enhanced absorption technologies of premium products. It contains folic acid rather than methylfolate, which may be problematic for some women.

Pros:

• Covers basic fertility nutrients
• Affordable option
• Easy-to-swallow capsules

Cons:

• Basic formulation without advanced ingredients
• Standard nutrient forms with limited bioavailability
• Minimal support for hormone regulation

5. Nutrazen Fertility Boost

Overall Rating: 7.4/10

Nutrazen offers the most budget-friendly option on our list. The supplement provides standard vitamins and minerals that support general reproductive health but lacks the sophistication of higher-rated formulations.

The company is transparent about their ingredient sourcing and manufacturing, but they use primarily synthetic nutrients and include several fillers and binders that may cause digestive discomfort in sensitive individuals.

Pros:

• Most affordable option
• Basic fertility nutrient coverage
• Widely available

Cons:

• Contains artificial fillers and binders
• Limited hormonal support
• Basic formulation with synthetic nutrients
• No specialised ingredients for comprehensive fertility support

Beyond Women’s Fertility: The Partner Perspective

What became increasingly clear during my research is that fertility is a shared journey. While women often bear the burden of supplementation, research shows that 40-50% of fertility challenges involve male factors.

When my husband joined me in optimising his nutrition through targeted supplementation, we saw dramatic improvements in his sperm parameters—something no amount of supplementation on my part alone could have achieved.

This discovery led me to investigate supplements designed specifically for male fertility, and I found that the same principles apply:

• Bioavailable nutrients are crucial
• Antioxidant protection is essential for sperm health
• Comprehensive formulations yield better results than single-nutrient approaches

The most effective approach appears to be coordinated supplementation for both partners, addressing the full spectrum of fertility factors simultaneously.

The Complete Fertility Solution: Men and Women’s Support

For couples serious about optimising their fertility, I found that the Wild Nutrition Men and Women’s Fertility Duo provides the most comprehensive approach. This pairing of the Food-Grown® Fertility Support for Women with the complementary men’s formula creates a synergistic effect that addresses all aspects of fertility from both sides of the equation.

The men’s formula focuses on sperm production, motility, and morphology through targeted nutrients like zinc, selenium, and CoQ10, while the women’s formula optimises egg quality, hormonal balance, and uterine receptivity.

Real-World Results: Thomas and Emma R. share their experience: “After two years of unexplained infertility and failed treatments, we decided to try the Wild Nutrition Fertility Duo. Within four months, my husband’s sperm parameters improved dramatically, and my cycle became more regular. We conceived naturally the following month and now have our beautiful daughter. We’re convinced the comprehensive approach made all the difference.”

The dual approach highlights an important truth often overlooked in fertility journeys: conception is a shared biological process that benefits from nutritional optimisation for both partners.

2025’s Top Fertility Supplement

Food-Grown® Fertility Support for Women

Overall, we highly recommend Wild Nutrition based on scientific review, real experiences and their customer review.

• Hormone support
• Supports fertility & reproduction
• Mental resilience
• Energy metabolism
• Antioxidant support
• Reduces tiredness

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Source

• Gaskins, Audrey J., and Jorge E. Chavarro. “Diet and fertility: a review.” American journal of obstetrics and gynecology 218.4 (2018): 379-389.
• Westphal, Lynn M., et al. “A nutritional supplement for improving fertility in women.” J Reprod Med 49.4 (2004): 289-93.
• Mora-Esteves, Cesar, and David Shin. “Nutrient supplementation: improving male fertility fourfold.” Seminars in Reproductive Medicine. Vol. 31. No. 04. Thieme Medical Publishers, 2013.
• Grajecki, Donata, Birgit-Christine Zyriax, and Kai J. Buhling. “The effect of micronutrient supplements on female fertility: a systematic review.” Archives of gynecology and obstetrics 285 (2012): 1463-1471.
• Collins, Gretchen Garbe, and Brooke V. Rossi. “The impact of lifestyle modifications, diet, and vitamin supplementation on natural fertility.” Fertility Research and Practice 1 (2015): 1-9.